Methotrexate is a medication that can be taken alone or with other medications. Your doctor has told you to take it exactly as he or she has instructed. If you take too much of it, it can have very serious side effects. It may take several weeks or months for you to notice or feel the benefits of taking this medication, so don’t stop taking it until your doctor tells you to. You should avoid drinking alcoholic beverages because it increases your risk of developing liver disease. Nausea, vomiting, weight loss, stomach discomfort, fatigue, and mouth sores are more common in newborns and smokers than in others. Some of these can be mitigated by taking folic acid, which your doctor may advise you to do. Inform your doctor if your symptoms do not improve or worsen. There could be ways to avoid or mitigate the severity of these consequences. It is a very powerful medication, and some people may experience severe side effects as a result of using it. This medication may impair your ability to fight infections and may cause complications with your blood, liver, or kidneys. Your doctor will advise you to have regular blood tests to monitor for these conditions. Before taking it, tell your doctor if you are pregnant, have stomach, liver, or kidney problems, or if you are currently taking any antibiotics or anti-infective medications. Many other medications may interact with or be affected by this medication, so make sure your healthcare team is aware of all medications you are taking. This medication should not be used during pregnancy or while nursing a newborn child. It could be dangerous to your child. It is advised that you and your spouse refrain from becoming pregnant or fathering a child for several months after your treatment has ended. When you are prescribed this medication, your doctor may order a variety of tests, including blood tests, x-rays, and physical examinations, both before and after therapy.